Scavenger Resins & Silica Scavengers

Scavenger resins selectively react with excess reagents and reaction by-products to quench reactions and allow removal of bound chemicals by simple filtration. Using scavenger resins, chemists can save time and achieve compound purities exceeding 85% for many frequently used reactions. Scavenger resins can be used as an alternative to extractions and chromatography, or to greatly speed initial cleanup of large reagent excesses prior to chromatography.

Biotage makes scavengers for a variety of electrophiles, nucleophiles, oxophilic, and other metals.

Since the reactive functionality is resin-bound, combinations of scavengers that would be incompatible in solution, such as acids with bases, can be used simultaneously to remove mixtures of impurities.

Biotage determines resin capacity by measuring the uptake of a model substrate. This provides a better measure of scavenging capacity than determinations based on elemental analysis. Scavenger resin applications typically require the addition of a three- to five-times excess of scavenger resin relative to the excess reagent or by-product to be scavenged. Scavenging of weakly reactive substrates can be accelerated by two sequential treatments with scavenger resin.