Myra Liquid Handling Systems
The Myra series represents a significant advancement in benchtop automation, featuring an integrated high-precision camera for automated calibration. Designed for accuracy at low volumes, it streamlines PCR/qPCR setup and NGS workflows while maintaining a compact footprint.
The series offers two primary configurations to meet different laboratory throughput requirements:
- Myra: The original, highly portable system featuring 6 SBS deck positions, ideal for standard qPCR setup and general liquid handling.
- Myra9: An evolution of the platform that expands the deck capacity to 9 SBS positions. By providing 50% more deck space without compromising the system's compact footprint, the Myra9 enables higher throughput workflows and more complex plate layouts.
The Myra system is designed to work in tandem with the Mic qPCR cycler. Both instruments operate from a single user interface, eliminating the need for manual data export or import. Sample names, assays, and thermal profiles are linked automatically to ensure a fast, error-free workflow.
| Feature | Myra | Myra9 |
| Level detection | Pressure sensing | Pressure sensing |
| Strategy | Single or multi-dispense | Single or multi-dispense |
| Deck capacity | 6 SBS positions | 9 SBS positions |
| Pipetting volume | 1-50 µL | 1-50 µL |
| Accuracy (1 µL) | <10% CV | <10% CV |
| Accuracy (5-50 µL) | <1% CV | <1% CV |
| Footprint (LxWxH) | 460mm x 360mm x 310mm | 468mm x 520 mm x 356 mm |
| Weight | ~10 KG | ~17 KG |
| Feature | Method |
| Tip diposal | Internal enclosed waste tub |
| UV decontamination | High intensity 70 mW 280 nm UV LED |
| HEPA air filtration | 99.98% at 0.3 µm |
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Myra features
qPCR setup
Seamlessly configure assays and transfer templates for high-throughput qPCR runs.
NGS Library Prep
Automate library quantification, normalization, and pooling with pre-configured scripts.
Integrated Camera Calibration
Myra is the first liquid handling system to utilize an integrated camera for plasticware calibration.
Advanced Automation
Streamlined NGS & Intelligent Normalization
Advanced NGS Workflow Automation
The Myra range functions as a dedicated NGS library prep workstation, streamlining the most error-sensitive stages of sequencing.
- Library Preparation: Automate reagent dispensing, enzymatic reactions, and bead-based cleanups with high-precision robotic pipetting.
- Magnetic Bead Handling: Utilize the integrated 96-well magnetic station for efficient DNA/RNA purification and fragment size selection.
- Scalable Throughput: The Myra9 variant supports up to 24 libraries in a single run, providing uniform sequencing coverage and consistent barcode balance.
Intelligent Normalization & Pooling
Manual normalization is prone to calculation errors and pipetting drift. Myra eliminates these risks through intelligent software integration:
- Automated Calculations: Simply import your sample names and concentrations; the software automatically calculates required diluent and sample volumes to reach your target concentration.
- Single-Step Execution: Myra can pool variable volumes into a single well, allowing normalization and pooling to occur simultaneously.
- Reliable Level Sensing: Pressure-based liquid level detection prevents under-aspiration, ensuring every library is represented equally in the final pool to maintain optimal read depth.
Assay Excellence
High-Throughput Kinase Screening & Dynamics
Master Universal Kinase Workflows
Transform complex kinase profiling into a high-precision, automated workflow. The Myra range is optimized for universal assays like ADP-Glo™, handling everything from initial enzymatic reactions to multi-step reagent additions. By delivering unmatched 1% CV precision (5–50 µL) and closed-loop position control, Myra ensures that every time-course measurement and dilution step is executed with the rigorous consistency these assays need.
Kinase assays are the backbone of drug discovery, requiring absolute precision to evaluate enzyme activity and inhibitor potency. The Myra liquid handling systems revolutionizes these assays by automating the conversion of ATP to ADP in a strictly controlled, time-course manner.
- Validated ADP-Glo™ Automation: Myra handles the critical two-step detection sequence. It precisely dispenses the ADP-Glo™ Reagent to terminate the kinase reaction and deplete residual ATP, followed by the addition of the Kinase Detection Reagent for luminescent quantification.
- Dynamic Michaelis-Menten Curves: The system facilitates the generation of high-quality data sets for kinetic analysis. By consistently replicating reaction conditions across varying substrate concentrations, Myra enables the precise determination of $V_{max}$ and $K_m$ parameters.
- Flexible Assay Formats: Beyond luminescence, Myra’s software-driven flexibility supports TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) and other sensitive fluorescence-based techniques, maximizing signal-to-noise ratios in 96 or 384-well formats.
- Intelligent Mixing & Precision: Utilize the vortex mixing feature to ensure reagent homogeneity and the integrated camera for precise tip positioning in small-aperture tubes, virtually eliminating manual pipetting drift and human error.
The Expert Assistant
MyraSim™
- Dynamically calculate optimal volumes required to complete the run without fail
- Analyzes every operation in your run to ensure every step will complete as expected – no surprises
- Optimisation feedback suggestions for better run performance
- Plan your run with confidence
Precision Liquid Handling
Simplify Your NGS Setup with Myra
Discover how the Myra liquid handling system integrates seamlessly with the Mic cycler to provide a complete, automated workflow for your laboratory. Our specialists can help you configure the ideal setup for your specific throughput needs.
