S-BIO® 3D Cell Culture, Organoid & Low-Adhesion Consumables
The S-BIO® product portfolio provides advanced surface technologies engineered to minimize non-specific sample loss, aggregate instability, and workflow variability in modern cell biology applications. The S-Bio® range uses the londstanding expertise of the Sumitomo motherhouse in polymer chemistry to produce the the highest reproducibility. The covalently grafted super-hydrophilic polymer surfaces of S-BIO cultureware and liquid handling consumables prevent non-specific cellular and biomolecular adhesion without leaching chemical additives into assays.
From high-recovery centrifugation tubes to ultra-low attachment (ULA) microplates and multi-organ microphysiological systems (MPS), the range delivers a standardized product that safeguards sample yield during cell harvesting, organoid expansion, and analytical downstream processing.
| Surface / Technology | Product Series | Primary Material / Format | Key Performance Characteristics |
Super-Hydrophilic Covalent Polymer | STEMFULL™ | PET / PP Conical Tubes (15 mL) | Minimizes cell adhesion; increases cell recovery rate in serum-free media. |
Super-Hydrophilic Covalent Polymer | PROTEOSAVE™ | PP Microtubes (0.5/1.5/2.0 mL) & Conical (50 mL) | Prevents protein and exosome adsorption; high chemical and thermal resistance (-80°C to 100°C). |
Ultra-Low Attachment (ULA) | PrimeSurface™ | Polystyrene Plates (24, 96, 384-well) & Dishes | Spontaneous, scaffold-free 3D spheroid and organoid formation; high size uniformity. |
Slit-Well Fluidics | PrimeSurface™ Slit-well | 96-Well Spindle-shaped Format | Enables 1-step media exchange for 96 wells; reduces pipetting time by >80%. |
Microfluidic Multi-Organ Connectivity | BioStellar™ MPS | 384-Well Plate Format (Up to 4 compartments) | Inter-organ drug metabolism, PK/PD modeling, and secondary toxicity screening. |
| Product Name | Catalog Number | Format / Well Shape | Packaging |
| STEMFULL™ 15 mL Conical Centrifuge Tube | MS-90150 | 15 mL Conical (PET) | 5 pcs/pk, 100 pcs/case |
| PROTEOSAVE™ 0.5 mL Microtube | MS-4255M | 0.5 mL Microtube (PP) | 100 pcs/pk, 500 pcs/case |
| PROTEOSAVE™ 1.5 mL Microtube | MS-4265M | 1.5 mL Microtube (PP) | 100 pcs/pk, 500 pcs/case |
| PROTEOSAVE™ 2.0 mL Microtube | MS-4270M | 2.0 mL Microtube (PP) | 100 pcs/pk, 500 pcs/case |
| PROTEOSAVE™ 50 mL Conical Centrifuge Tube | MS-52550 | 50 mL Conical (PP) | 5 pcs/pk, 100 pcs/case |
| PrimeSurface™ Plate 96U | MS-9096UZ | 96-well, Clear, U-shaped (300 µL) | 20 pcs/case |
| PrimeSurface™ Plate 96W | MS-9096WZ | 96-well, White, U-shaped (300 µL) | 20 pcs/case |
| PrimeSurface™ Plate 96M | MS-9096MZ | 96-well, Clear, Spindle-shaped (200 µL) | 20 pcs/case |
| PrimeSurface™ Plate 96V | MS-9096VZ | 96-well, Clear, V-shaped (300 µL) | 20 pcs/case |
| PrimeSurface™ Plate Slit-well 96S | MS-9096S | 96-well, Clear, Spindle-shaped | 20 pcs/case |
| PrimeSurface™ Plate 384U | MS-9384U | 384-well, Clear, U-shaped (100 µL) | 20 pcs/case |
| PrimeSurface™ Plate 384W | MS-9384W | 384-well, White, U-shaped (100 µL) | 20 pcs/case |
| PrimeSurface™ Plate 24F | MS-90240 | 24-well, Clear, Flat bottom (3.4 mL) | 10 pcs/case |
| PrimeSurface™ Dish 35 | MS-90350 | 35 mm Dish, Flat bottom (9 cm²) | 20 pcs/case |
| PrimeSurface™ Dish 60 | MS-90600 | 60 mm Dish, Flat bottom (21 cm²) | 20 pcs/case |
| PrimeSurface™ Dish 90 | MS-90900 | 90 mm Dish, Flat bottom (57 cm²) | 20 pcs/case |
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Integrated Organoid Solutions
Streamlined Architecture for 3D Biological Models
The S-BIO product ecosystem provides structural support across every operational phase of organoid handling:
STEMFULL™ tubes prevent silent adhesion loss during single-cell suspension and harvest steps.
PrimeSurface™ ULA plates drive uniform aggregate self-assembly and maintain long-term survival.
BioStellar™ MPS microfluidic plates connect distinct tissue organoids to model complex inter-organ pharmacokinetics and secondary toxicity.
Product Categories
Specialized Consumables & Cultureware
STEMFULL™ Low Adhesion Centrifuge Tubes
Covalently modified polymer surface engineered to recover rare cells, stem cells, and dissociated organoid suspensions under serum-free conditions.
PrimeSurface™ 3D Culture Plates & Dishes
Ultra-low attachment plates offering diverse well geometries (U, V, M, Slit-well) to reproducibly promote spontaneous, uniform spheroid self-assembly.
BioStellar™ Multi-Organ MPS Plate
Microphysiological platform connecting up to four tissue compartments to evaluate inter-organ metabolic drug responses and toxicity.
Technical Validation
Application Performance Data
Non-specific cell adhesion to container walls causes unrecorded sample loss during cell handling, particularly under serum-free conditions.
- Intestinal Organoids: STEMFULL™ 15 mL conical tubes demonstrated a 128% cell recovery rate compared to standard polypropylene tubes (average cell count 62,000 vs. 48,333) during serum-free dissociation.
- Single-Cell Analysis: Utilized in endometrial organoid (AO-EMO) processing protocols to prevent cell adhesion loss during sample preparation for single-cell RNA sequencing (scRNA-seq).
PrimeSurface™ cultureware minimizes aggregate loss while supporting structural consistency across extended culture periods.
- Size Reproducibility: Culturing cortical organoids in PrimeSurface™ 96 Slit-well plates reduced the diameter coefficient of variation (CV) to 12.76%, compared to 25.50% in standard dish controls.
- Fluidic Efficiency: The 96 Slit-well format enables simultaneous medium aspiration and dispensing across all wells in a single fluidic step, reducing pipetting duration by over 80% while protecting aggregates from shear stress.
Coupling organoids derived in PrimeSurface™ plates with the BioStellar™ MPS microfluidic system creates functional multi-organ research models.
- Metabolic Inter-Organ Toxicity: Physical connection of liver organoids (LO) and CNS organoids (CNSO) successfully demonstrated secondary neurotoxicity following hepatic metabolic activation of Cyclophosphamide (CP), observed via dose-dependent NeuN reduction and increased γH2AX DNA damage markers.
Polymer Chemistry
Surface Engineering & Covalent Grafting Technology
Unmodified polypropylene and polystyrene surfaces exhibit natural hydrophobicity, leading to non-specific adsorption of proteins, hydrophobic peptides, and whole cells. S-BIO consumables resolve surface binding through advanced polymer chemistry developed by Sumitomo Bakelite:
An engineered ultra-hydrophilic polymer rich in hydroxyl (-OH) groups retains a localized water layer at the plastic surface, establishing a physical barrier against biomolecular adhesion.
The polymer layer is chemically grafted onto the plastic substrate via light and thermal photocrosslinking, preventing coating elution or leachable contamination during LC-MS and HPLC analytical workflows.
Covalently bound surfaces retain structural integrity when exposed to boiling (100°C), organic solvents (methanol, acetonitrile), detergents, and deep freezing (-80°C).
Frequently Asked Questions
Technical details regarding low-adhesion centrifuge tubes, surface chemistry, and compatibility.
Low-adhesion tubes feature a permanently bound, ultra-hydrophilic surface layer rich in hydroxyl (-OH) groups. This coating binds water molecules at the interface to create a protective water shield, preventing cells, hydrophobic peptides, and proteins from contacting raw plastic walls.
No. S-BIO polymer surface coatings are covalently grafted onto the tube walls through photocrosslinking. Unlike spray-on surfactants or physical coatings, the material does not elute into solutions, preventing artifact peaks in sensitive LC-MS or mass spectrometry assays.
Yes. Non-specific cell binding is significantly higher in serum-free media due to the absence of competing serum proteins. S-BIO low-adhesion tubes are specifically validated to maximize recovery of stem cells, rare primary cells, and single-cell organoid suspensions under serum-free conditions.
Yes. Because the hydrophilic surface matrix is covalently bonded to a robust polypropylene base, the tubes maintain non-binding performance in the presence of organic solvents like methanol, ethanol, and acetonitrile, as well as common laboratory surfactants.
The tubes maintain structural integrity across standard laboratory temperature extremes, supporting long-term sample storage down to -80°C and short-term thermal processing up to 100°C (boiling).
Resin-blended plastics integrate additives into the raw polymer mix to smooth the surface, whereas covalently coated tubes utilize an active hydrophilic hydroxyl layer. This dense water shield offers superior protection against hydrophobic peptide and cell binding, particularly at extremely low sample concentrations.
Yes. Consumables intended for cell processing are provided sterile and packaged to maintain cleanliness standards required for cell isolation, organoid passaging, and single-cell analysis.
The product range includes 0.5 mL, 1.5 mL, and 2.0 mL microtubes for analytical liquid handling, as well as 15 mL and 50 mL conical centrifuge tubes for larger volume cell harvesting and washes.